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Hyalgan(R) was the first viscosupplement approved by the FDA in 1997. It contains a high molecular weight fraction of purified natural sodium hyaluronate, extracted from rooster combs. It comes in a 5-injection regimen given weekly providing pain relief for up to 6 months. Some patients benefit from the first three injections given at weekly intervals.

The preparation has not been found to interfere with any other medication for osteoarthritis or any other medical condition. It has also been proven safe for repeat treatment if needed.

It is contraindicated in patients with hypersensitivity to hyaluronic acid preparations. Intra-articular injections are contraindicated in cases of already infected skin or in presence of skin disease at the injection site to reduce the potential for developing septic arthritis. Patients are encouraged to avoid any strenuous or prolonged activities involving their hands for the first 48 hours after the intra-articular injection.


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