DNA nanoparticles reduce joint inflammation

Published date : 27 May 2012
Article date : 27 May 2012

In a study published in the Journal of Immunology, researchers from the Georgia Health Sciences University have demonstrated that nanoparticles designed to deliver nucleic acids into cells and tissues were able to reduce inflammation in joints by virtue of their presence alone.  The nanoparticles overcame the immune stimulation used in the mouse model without the additional nucleic acids they were designed to deliver.  The team have work to do to identify the best polymer to use clinically, but this study suggests there is potential for development of a new class of medical device.




Huang L, Lemos HP, Li L, Li M, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee JR, Munn DH, Mellor AL. Engineering DNA Nanoparticles as Immunomodulatory Reagents that Activate Regulatory T Cells. J Immunol. 2012 May 15;188(10):4913-20. Epub 2012 Apr 18.




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