SIRTeX Medical  SIR-Spheres Y90 Resin Microspheres   | Which Medical Device

SIR-Spheres Y90 Resin Microspheres

Added Apr 13, 2013

Manufactured by SIRTeX Medical

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Posted Apr 1, 2016

NICE has developed a medtech innovation briefing (MIB) on SIR?Spheres for treating inoperable hepatocellular carcinoma.

Credits: NICE

SIRFLOX was a randomized, multicenter trial designed to assess the efficacy and safety of adding
selective internal radiation therapy (SIRT) using yttrium-90 resin microspheres to standard fluorouracil,
leucovorin, and oxaliplatin (FOLFOX)?based chemotherapy in patients with previously
untreated metastatic colorectal cancer

Credits: Journal of Clinical Oncology

SIRFLOX: Randomized phase III trial comparing first-line mFOLFOX6 ± bevacizumab (bev) versus mFOLFOX6 + selective internal radiation therapy (SIRT) ± bev in patients (pts) with metastatic colorectal cancer (mCRC).

Credits: ASCO

In 2012, there were 447 000 new cases of colorectal cancer (CRC) in Europe. CRC is the second most frequent cancer and represents 13.2% and 12.7% of all cancer cases in men and women, respectively. CRC was responsible for 215 000 deaths in Europe in 2012. This represents 11.6% and 13.0% of all cancer
deaths in men and women, respectively [1].Approximately 25% of patients present with metastases at initial diagnosis and almost 50% of patients with CRC will develop metastases contributing to the high mortality rates reported for CRC. The CRC-related 5-year survival rate approaches 60%.

Credits: Oxford

A multicenter analysis was conducted to evaluate the main prognostic factors driving survival
after radioembolization using yttrium-90?labeled resin microspheres in patients with hepatocellular
carcinoma at eight European centers.

Credits: Wiley online library

Reports show that SIRT may downsize inoperable liver tumors to resection, but no robust studies on post-surgical safety outcomes exist. P4S is an international, multicenter, retrospective study to assess outcomes of liver resection or transplantation following SIRT. This analysis compared outcomes in resected patients with or without prior SIRT exposure to FLR.

Credits: JVIR- Journal of Vascular and Interventional Radiology

Since the first experimental patients were treated in the late 1980s, numerous reports
detailing the use of SIR-Spheres microspheres have appeared in the literature. These
papers have been from a variety of clinical trial and experiential settings and are presented
here as a bibliography in different tumour types and in chronological order (latest first). In
addition, the interim results of other studies that have as yet only been presented at scientific
meetings are provided separately in each tumour type.

Credits: SIR-Spheres microspheres Bibliography: October 2012

The purpose of this study was to evaluate the effectiveness of colorectal cancer (CRC) liver metastasis radioembolization with yttrium-90 (Y90), assessing toxicity and survival rates in patients with no response to chemotherapy through our 3-year experience.

Credits: Cardiovasc Intervent Radiol. 2009 Nov;32(6):1179-86

Almost half the patients with colorectal cancer will develop liver metastasis at some stage during their disease. Potentially curative surgical resection is possible in some of these patients. In those patients unsuitable for surgery, treatment with systemic chemotherapy and external radiation therapy is relatively ineffective. Many studies have described the successful use of selective internal radiation therapy (SIRT) with 90Y-SIR-Spheres microspheres in patients with inoperable liver metastasis. The authors report on a patient who has been in complete remission for 1 year after treatment with SIRT

Credits: BMJ Case Rep. 2011 May 16;2011

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